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KMID : 0854720120320040264
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 4 p.264 ~ p.267
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A Case of Cesarean Section Delivery in a Patient with Hereditary Angioedema
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Lee Suh-Young
Lee Seung-Eun
Kim Min-Hye
Song Woo-Jung
Kang Hye-Ryun
Min Kyung-Up
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Abstract
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Background: Hereditary angioedema is a rare disease caused by a deficiency of C1 inhibitor and inherited in an
autosomal dominant manner. It leads to episodic abdominal pain and angioedema which can be life-threatening. Associations between hereditary angioedema and pregnancy have been reported in the literature. The frequency of symptoms increases during pregnancy and the postpartum period. While complications during vaginal delivery are generally known to be rare in patients with heterditary angioedema, acute attack of heterditary angioedema may occur during Cesarean section.
Methods: A 34-year-old pregnant woman was admitted for the induction of labor with suspected preeclampsia. The patient was diagnosed with hereditary angioedema 5 years ago and treated with tranexamic acid when needed. During the first trimester of pregnancy, the incidence of attacks increased but she did not take any medication. She had prophylactic tranexamic acid for 2 weeks before delivery. Emergency Cesarean section was performed due to fetal deceleration that occurred during labor induction.
Results: After injection of a C1 inhibitor in the phase of anesthesia induction, delivery was successful without any complications.
Conclusion: We report a case of Cesarean section delivery with a prophylactic use of a C1 inhibitor in a patient with hereditary angioedema.
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KEYWORD
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Hereditaty angioedema, Cesarean section, Complement C1 inhibitor protein
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